June 26, 2004
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ICOS Corporation

Staff Scientist, Pre-Clinical Research, ADME

Location(s): Bothell WA

Company Overview

ICOS Corporation, based in the Seattle, Washington area, has spent more than a decade building a world-class research and development organization. Our lead product Cialis® (tadalifil) for the treatment of erectile dysfunction, recently received US FDA approval and is currently launched in over 50 countries worldwide. ICOS is committed to advancing science in the areas of protein based and small molecule therapeutics.

If you are a scientific researcher with experience in doing pre-clinical research in the area of ADME and are interested in working with a fast growing company that is building a strong pipeline of pharmaceutical products in multiple stages of development, then consider this opportunity with ICOS Corporation.


You will work closely with project development teams to support our Preclinical Department in meeting significant challenges in the areas of pharmacokinetics and drug metabolism. Responsibilities include designing and interpreting in vitro and in vivo studies, which will evaluate the adsorption, distribution, metabolism and elimination of compounds taken forward into early clinical development. You will also interact with the research discovery team to identify novel therapeutics for the treatment of inflammation, neurologic diseases and cancer.


  • PhD with a few years of pharmacology, pharmacokinectics and drug metabolism experience within the pharmaceutical industry or academic setting.
  • Significant experience with in vivo pharmacokinetic, mass balance, biodistribution and metabolism studies.
  • Experience in the design and interpretation of in vivo pharmacokinetic, adsorption/biodistribution/elimination studies is essential.
  • Experience in PK/PD analyses (including WINNONLIN, or KInetica, ADAPT, NONMEN and statistical programming.
  • Strong background with analytical instrumentation (LC, LC-MS, LC MS/MS) and assay validation.

Additional Skills

  • Strong collaborative skills.
  • Demonstrated management and supervisory skills are desirable.
  • Ability to work effectively in a fast paced, rapidly growing environment.
  • Excellent written and oral communication skills.

ICOS offers a highly competitive compensation package and a friendly, collaborative culture that values personal initiative and professional achievement. EOE

For immediate consideration visit www.icos.com and apply directly for this position or email your resume directly to kfenstermacher@icos.com highlighting this position.

Learn more about ICOS’ philosophies, attributes, financial information, and more by visiting our web site at: www.ICOS.com.

ICOS Corporation
Reference Job Code: 1608GT0104

Email: kfenstermacher@icos.com

ICOS Corporation is an Equal Opportunity Employer

Submitted: 01/30/2004

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